Kidney Stone

A kidney stone or renal calculus is a crystal concentration formed in the kidneys. Nephrolithiasis is formed from the minerals consumed in the diet and is largely composed of calcium. 75% of kidney stones are calcium stones. While Struvite stones are more commonly noticed in women, Uric acid stone can occur in men and women. Typically men are more affected by kidney stones than women. In most cases, the kidney stones are expelled by the body in the urine and no symptoms are noticed. But as the kidney stone grows in size, it can lead to pain and other symptoms. This is because of the obstruction to the ureters. A person suffering kidney stones feels pain in the area between the ribs and hip or lower abdomen and groin. Intermittent pain or renal colic is felt in spasms. It is sometimes accompanied by fever, blood and pus in the urine and pain on urination. There might be nausea and vomiting. There might be abnormal color of the urine.

Some foods that might increase the risk of kidney stone formation are refined sugars, sodium, vast quantities of animal protein and cola. Inadequate consumption of water adds to the risk factors. Those taking calcium supplements might also notice higher incidences of renal stone formation. This does not happen with high consumption of dietary calcium. Sodium, Uric acid and sulfurous amino acids also contribute to the formation of kidney stones. On the other hand, magnesium and potassium reduce urinary crystal formation by excreting citrate. Those with a family history of kidney stones are at higher risk of renal stones. Persons suffering kidney disorders, UTI and cystic kidney disease are also susceptible to kidney stones. Hyperoxaluria is a condition where the body produces too much oxalate. When this quantity is too large to be dissolved in urine, it leads to the formation of renal stones.

Ultrasound is done to confirm the presence of kidney stones. X-rays and IVP (intravenous pyelogram) aid in imaging the renal stone. Kidney function test and blood tests are also done. The size of kidney stones can range from a small grain of sand to a pearl. It can be smooth or jagged. Over time, renal stones can cause irreversible kidney damage. Most small stones in the kidney do not need treatment or removal. But if the kidney stones cause urine blockage, bleeding, infection or keep growing in size, they need to be removed. Some kidney stones, especially those consisting of uric acid or cystine can be treated with medicines. Else endoscopic removal of kidney stones with a uterescope is done. Lithotripsy is often used to break the stone into smaller pieces so that they can be flushed with the urine.

Burst Wave Lithotripsy : A recent feasibility study published in The Journal of Urology highlights a novel approach that may alleviate the pain associated with the treatment of renal calculus (Kidney stones) . This new technique combines two ultrasound technologies and offers an alternative to the current standard procedure - shock wave lithotripsy, which requires sedation.

This new approach involves the use of a handheld transducer placed on the skin to direct ultrasound waves towards the stone. The ultrasound can then be used in two ways. First, ultrasound propulsion can be utilized to move and reposition the stones, thereby facilitating their passage. Second, burst wave lithotripsy (BWL) can be employed to break up the stone into smaller fragments.

Notably, this technology has the advantage of being minimally invasive and painless, and it does not require anesthesia. This makes it a desirable option for patients who may not be able to tolerate sedation or anesthesia.

Kidney stones can be extremely painful and are known to afflict about 10 % of Americans. While patients with these stones are typically advised to wait for the stones to pass on their own, this can be a lengthy process.

Actually we may owe NASA for this technique to zapping kidney stones, because several years ago, NASA forked out funds for a study primarily intended to break up or move the kidney stones without anesthesia for Astronauts on long space flights where their physical movement will be restricted for longer duration - susceptible to the formation of stones due to factors such as microgravity and fluid shifts. When the study reported that BWL could shift or fracture the stones with ease, it came into general usage.

Lithotripsy

Lithotripsy is a medical procedure wherein shock waves are used to break up kidney stones, ureter or bladder. Extra corporeal shock wave lithotripsy is the most commonly used type. The shock wave is termed extra corporeal as the shock wave is generated outside the body. It is a non-invasive technique. This procedure is used when the stone is too large to pass out on its own or if the stone is stuck in the ureter.

Lithotripsy Procedure

Prior to the treatment the following is followed:

• Complete physical examination
  
• Urine analysis
  
• Blood test
  
• IVP: intravenous pyelogram is used to locate the stone and understand the extent of blockage
  
• ECG for people with history of heart problems
  

Patient is made to lie down on a comfortable cushion/bed (usually water-filled). A mild sedative, pain killer and antibiotics are administered before the procedure so as to prevent any kind of discomfort, pain or infection. High energy sound waves pass through the body until they hit upon the kidney stone. The machine through which the waves is passed is called as the lithotripter. The kidney stone is broken into several pieces by the wave. The broken stone debris is called gravel. This gravel passes out while urinating. Usually there is no damage to skin or other internal organs as the shock waves are not focused on them. Generally after lithotripsy, people tend to bleed while urinating. This is common and will stop on its own. People who have undergone the procedure should drink plenty of water so as to flush the gravel out. A few patients may report abdominal pain which subsides on its own after a few days. If the symptoms persist, it is suggested that the patient visit the physician.

Lithotripsy should not be performed on people with skeletal deformities, persons with uncontrolled bleeding and pregnant women. Some of the possible side-effects include:

• Kidney infection
  
• Ulcers in the stomach or small intestine.
  
• Pieces of the stone may block free urine passage.
  
• Pieces of stone might be left behind in the body.
  
• Bleeding (internal)
  
• Very rarely stones do not get completely fragmented during the first time and so the procedure might have to be repeated again.
  

Urinalysis

Urinalysis refers to a group of tests conducted on urine sample to determine the various chemical components of the urine. Urine analysis is an examination of the urine sample that gives useful information regarding the renal and metabolic disorders, kidney or urinary tract infections, diabetes and host of other diseases. Urinalysis does not diagnose the disease itself, rather the presence of abnormal substances in the urine that will help direct the course of further evaluation and diagnosis. Depending upon the symptoms reported, urinalysis is conducted in three different phases.

1. Visual analysis or physical examination
2. Chemical analysis
3. Microscopic analysis

Physical examination of urine

Color: Normally urine looks pale yellow; any change in the color of the urine indicates some abnormality, for example dark yellow urine indicates dehydration whereas bile pigments cause brown urine. Urine turns red when there is blood in the urine. Sometimes consumption of certain foods such as blackberries, rhubarb and beets turns the urine red.

Clarity: Normal urine is usually clear, cloudy urine indicates the presence of bacteria, blood, sperm, crystals, or mucus. Odor: Normal urine has a nutty odor to it whereas diabetes gives urine a fruity odor and bacterial infections lead to bad odor of the urine.

Chemical analysis of urine

Chemical examination is normally conducted with the help of the dipstick. The change in the colors of the different pads on the dipstick indicates varied health conditions.

pH balance: pH balance measures the acidic and alkaline balance of the urine. The lower or higher pH indicates kidney disorders. pH balance can be changed by consuming the appropriate diet.

Protein: Protein test normally involves examining the albumin levels in the urine. The elevated albumin level is the initial symptom of kidney disorder.

Glucose: Higher glucose levels in the urine is associated with diabetes and other conditions like hormonal disorders, liver disease and pregnancy.

Ketones: When the body does not get enough carbohydrates, it starts metabolizing the fats to gather energy and in process releases ketones into the urine, thus indicating the low levels of insulin.

Blood: Urine is also tested for the presence of red blood cells. Various kidney and urinary tract diseases and trauma, injury, medications, smoking, or strenuous exercise lead to the contamination of urine with the blood.

Nitrites: UTI or urinary tract infection changes the urinary nitrates into nitrites. Therefore the presence of nitrites indicates the presence of UTI. Likewise urine is also tested for Leukocytes as they too indicate the presence of UTI.

Microscopic urine analysis

This test involves collection of urine in centrifuge to be spun for few minutes, so that sediments settle at the bottom. The sediment substance is then spread on the slide and examined under microscope. The urine is tested for the following:

If the urine shows red or white blood cells, it signals an inflammation, kidney disease or an injury of the ureters, bladder, or urethra. Microscopic examination of urine also reveals the presence of crystals. Large number of Crystals in the urine indicates dehydration, pH imbalance, UTI or a condition called Urolithiasis, signifying kidney stone or bladder stones. Urine is also tested for bacteria, yeast cells, or parasites, as any of these organisms in the urine signals infection. Increased quantity of epithelial cells in urine could indicate some health problems.